A novel assay for functional determination of direct oral anticoagulants. For Research Use Only, not for patient diagnosis or treatment

The PT DOAC assay is used for functional determination of the extrinsic pathway of the coagulation cascade in patients treated with direct oral anticoagulants (DOACs).

A simple and rapid assay for functional determination of DOAC effect has been needed since the introduction of DOACs. A major drawback of using conventional coagulation tests for estimation of DOAC effect is the substantial variability in the sensitivity to DOACs amongst different reagents. Medirox has taken this disadvantage into account in the development of MRX PT DOAC. This novel prothrombin time (PT) method utilizes a concept already proven for warfarins. As a conventional PT determines the effect of warfarin and not the concentration, PT DOAC determines the effect of DOACs and not the concentration. Furthermore, only one reagent is needed to detect the effect of all the DOACs. The method is patented in Europe (EP31416347) and a world-wide patent (WO2015177293) is pending.

We are currently looking for collaborators that are interested in working with us to evaluate the clinical usefulness of this For Research Use Only Product.

Functional determination of DOAC effect, not concentration

Highly DOAC sensitive

Only one reagent is needed to detect all DOACs

Familiar method to the routine laboratories

Details & typical data

Product form: Lyophilised and liquid components
Origin: Reagent: lyophilised rabbit brain thromboplastin, plasma of bovine origin
Calibrators/Controls: human citrated plasma
Additional products needed: MRX PT DOAC Kit is a complete assay, no other products are needed
No interference with: Hemoglobin ≤ 10 g/L, bilirubin ≤ 500 mg/L, lipids ≤ 2.5 g/L.

Stability & storage

Storage: 2-8 °C
Shelf-life: 12 months
Reconstituted solution: Reagent: 4 days at 2-8 °C
Calibrators: 4 hours at 15-25 °C
Controls: 24 hours at 15-25 °C

Ordering information

Ref. No Product description Size
MRX1100 MRX PT DOAC Kit 1 kit
MRX PT DOAC Reagent 20 x 4 mL
MRX PT DOAC Reagent Buffer 20 x 4 mL
MRX PT DOAC Sample Diluent 1 x 10 mL
MRX PT DOAC Calibrator A, B, C 6 x 1 mL (2 x 1 mL per level)
MRX PT DOAC Control Normal, Low, High 30 x 1 mL (10 x 1 mL per level)
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