The PT DOAC assay is used for functional determination of the extrinsic pathway of the coagulation cascade in patients treated with direct oral anticoagulants (DOACs).
A simple and rapid assay for functional determination of DOAC effect has been needed since the introduction of DOACs. A major drawback of using conventional coagulation tests for estimation of DOAC effect is the substantial variability in the sensitivity to DOACs amongst different reagents. Medirox has taken this disadvantage into account in the development of MRX PT DOAC. This novel prothrombin time (PT) method utilizes a concept already proven for warfarins. As a conventional PT determines the effect of warfarin and not the concentration, PT DOAC determines the effect of DOACs and not the concentration. Furthermore, only one reagent is needed to detect the effect of all the DOACs. The method is patented in Europe (EP31416347) and a world-wide patent (WO2015177293) is pending.
We are currently looking for collaborators that are interested in working with us to evaluate the clinical usefulness of this For Research Use Only Product.
Functional determination of DOAC effect, not concentration
Highly DOAC sensitive
Only one reagent is needed to detect all DOACs
Familiar method to the routine laboratories
Details & typical data
|Product form:||Lyophilised and liquid components|
Reagent: lyophilised rabbit brain thromboplastin, plasma of bovine origin
Calibrators/Controls: human citrated plasma
|Additional products needed:||MRX PT DOAC Kit is a complete assay, no other products are needed|
|No interference with:||Hemoglobin ≤ 10 g/L, bilirubin ≤ 500 mg/L, lipids ≤ 2.5 g/L.|
Stability & storage
Reagent: 4 days at 2-8 °C
Calibrators: 4 hours at 15-25 °C
Controls: 24 hours at 15-25 °C
|Ref. No||Product description||Size|
|MRX1100||MRX PT DOAC Kit||1 kit|
|MRX PT DOAC Reagent||20 x 4 mL|
|MRX PT DOAC Reagent Buffer||20 x 4 mL|
|MRX PT DOAC Sample Diluent||1 x 10 mL|
|MRX PT DOAC Calibrator A, B, C||6 x 1 mL (2 x 1 mL per level)|
|MRX PT DOAC Control Normal, Low, High||30 x 1 mL (10 x 1 mL per level)|