MRX FDP reagent consists of sub-micron sized polystyrene particles coupled to monoclonal antibodies specific for FDP. When the reagent is exposed to an FDP containing plasma sample, the particles will agglutinate, giving rise to increased light-scattering. When exposed to the appropriate wavelength of light, the increase in measured turbidity, or light-scattering, is proportional to the amount of FDP in the sample. MRX FDP is suitable for automatic coagulation and clinical-laboratory instruments using turbidimetric detection in the 500 - 650 nm wavelength range.
Specific for fibrin- and fibrinogen degradation products
Good correlation to existing FDP assays
Optimised for instruments in the 500-650 wavelength range
The determination of fibrinogen degradation products (FDP) has become a prevalent aid in the diagnosis of disseminated intravascular coagulation (DIC), pulmonary embolism (PE), deep vein thrombosis (DVT) and acute aortic dissection (AAD). The FDP assay is commonly used in some markets where the laboratories run the FDP assay in parallel with the D-Dimer assay.
The product is used for quantitative determination of FDP in human plasma. FDP is a generic name for all fragments formed during plasmin cleavage of fibrin and fibrinogen. Whereas plasmin degradation of fibrin occurs in presence of a fibrin clot, plasmin degradation of fibrinogen occurs during over activation of the
coagulation system causing systemic fibrinolysis. During systemic fibrinolysis, seen in patients with disseminated intravascular coagulation (DIC), activated plasmin cleaves circulating fibrinogen, rendering elevated levels of fibrinogen degradation products in the blood stream.
Sensitivity & specificity
Details & typical data
|Product form:||Liquid components|
• MRX132: 5 mL latex + 9 mL reaction buffer
• Other filling volumes upon request
|Additional products needed:||
•Sample Diluent (0,9 % NaCl) (MRX184) for calibrator dilutions
•FDP Clear Low/High Control (MRX191/MRX192)
•FDP Clear Calibrator (MRX1207)
|Linear range:||0.9-113 ug/mL|
|No interference with:||Hemoglobin <2000 mg/dL, Bilirubin <50 mg/dL, Triglycerides <2190 mg/dL, UFH <110 U/mL and LMWH <1100 U/mL|
Stability & storage
|Shelf-life:||24 months at 2-8 °C|
|Open-vial stability:||4 weeks at 2-8 °C|
|Reference number||Product description||Size|
|MRX132||FDP 550 nm (latex + reaction buffer)||5x5 mL + 5x9 mL|
|MRX184||Sample Diluent (0,9% NaCl)||1x8 mL|
|MRX191||FDP Clear Low Control||10x1 mL|
|MRX192||FDP Clear High Control||10x1 mL|
|MRX1207||FDP Clear Calibrator (5-Levels)||5x1 mL|
MRX FDP product line
MRX132500-650 nm FDP kit
5x5 mL Latex
5x9 mL Reaction buffer
Sample Diluent (0,9% NaCl) for purpose of dilution of test plasmas and calibrator plasmas for the Fib Clauss, Antithrombin and D-Dimer assays.
FDP Clear Calibration Kit consists of five vials with different levels of human-derived fibrin and fibrinogen degradation products, stored and lyophilized in a matrix containing buffer and bulking material.
MRX191FDP Clear Low Control
MRX192FDP Clear High Control
All Coagulation Reagents
Latex-based liquid components for quantifying free Protein S in human citrated plasma using readers with wavelengths 600-800nm.
MRX Fib Clauss
Lyophilised reagents for quantifying fibrinogen in human citrated plasma, according to the Clauss method.
FXa-based chromogenic assay consisting of liquid components for quantifying functional Antithrombin activity in human citrated plasma.
MRX PT Quick
PT reagent from rabbit brain origin with an ISI ~1 for responsive determination of Prothrombin Time in citrated human plasma.
Liquid compontent kits containing phospholipid extract and silica contact activator. Sensitive to heparin as well as factors and insensitive to lupus anticoagulant.
Latex-based liquid components for quantifying D-dimer fragments in human citrated plasma using readers with wavelengths 350-900nm.
MRX PT Owren’s
The predominantly used PT method in the Nordics as it is less sensitive to interferences. The assay can be used with both whole blood and plasma.
MRX Thrombin Time
Two different lyophilised reagents for detection of fibrinogen abnormalities, and the presence of heparin and other thrombin inhibitors in human citrated plasma.