MRX FDP

MRX FDP is a latex immunoassay for quantifying fibrin and fibrinogen degradation products in human plasma using readers with wavelengths 500-650nm.

MRX FDP reagent consists of sub-micron sized polystyrene particles coupled to monoclonal antibodies specific for FDP. When the reagent is exposed to an FDP containing plasma sample, the particles will agglutinate, giving rise to increased light-scattering. When exposed to the appropriate wavelength of light, the increase in measured turbidity, or light-scattering, is proportional to the amount of FDP in the sample. MRX FDP is suitable for automatic coagulation and clinical-laboratory instruments using turbidimetric detection in the 500 - 650 nm wavelength range.

Specific for fibrin- and fibrinogen degradation products

Good correlation to existing FDP assays

Optimised for instruments in the 500-650 wavelength range

 

General Description

The determination of fibrinogen degradation products (FDP) has become a prevalent aid in the diagnosis of disseminated intravascular coagulation (DIC), pulmonary embolism (PE), deep vein thrombosis (DVT) and acute aortic dissection (AAD). The FDP assay is commonly used in some markets where the laboratories run the FDP assay in parallel with the D-Dimer assay.

Performance Characteristics

The product is used for quantitative determination of FDP in human plasma. FDP is a generic name for all fragments formed during plasmin cleavage of fibrin and fibrinogen. Whereas plasmin degradation of fibrin occurs in presence of a fibrin clot, plasmin degradation of fibrinogen occurs during over activation of the 

coagulation system causing systemic fibrinolysis. During systemic fibrinolysis, seen in patients with disseminated intravascular coagulation (DIC), activated plasmin cleaves circulating fibrinogen, rendering elevated levels of fibrinogen degradation products in the blood stream. 

Sensitivity & specificity

Details & typical data

Product form: Liquid components
Available volumes: • MRX132: 5 mL latex + 9 mL reaction buffer
• Other filling volumes upon request
Origin: Monoclonal antibodies
Additional products needed: •Sample Diluent (0,9 % NaCl) (MRX184) for calibrator dilutions
•FDP Clear Low/High Control (MRX191/MRX192)
•FDP Clear Calibrator (MRX1207)
Wavelength: 500-650 nm
Linear range: 0.9-113 ug/mL
No interference with: Hemoglobin <2000 mg/dL, Bilirubin <50 mg/dL, Triglycerides <2190 mg/dL, UFH <110 U/mL and LMWH <1100 U/mL

Stability & storage

Storage: 2-8 °C
Shelf-life: 24 months at 2-8 °C
Open-vial stability: 4 weeks at 2-8 °C

Ordering information

Reference number Product description Size
MRX132 FDP 550 nm (latex + reaction buffer) 5x5 mL + 5x9 mL
MRX184 Sample Diluent (0,9% NaCl) 1x8 mL
MRX191 FDP Clear Low Control 10x1 mL
MRX192 FDP Clear High Control 10x1 mL
MRX1207 FDP Clear Calibrator (5-Levels) 5x1 mL

MRX FDP product line

Item & description
Pack size

MRX132

500-650 nm FDP kit

5x5 mL Latex

5x9 mL Reaction buffer

 

MRX184

Sample Diluent (0,9% NaCl) for purpose of dilution of test plasmas and calibrator plasmas for the Fib Clauss, Antithrombin and D-Dimer assays.

10x8 mL

MRX1207

FDP Clear Calibration Kit consists of five vials with different levels of human-derived fibrin and fibrinogen degradation products, stored and lyophilized in a matrix containing buffer and bulking material.

1x1 mL 

MRX191

FDP Clear Low Control

10x1 mL

MRX192

FDP Clear High Control

10x1 mL

 
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If you have any further thoughts or questions, don’t hesitate to call us at +46 (0)155 45 44 10.