MRX D-Dimer

Latex-based liquid components for quantifying D-dimer fragments in human citrated plasma using readers with wavelengths 350-900nm.

D-dimer is a key indicator of thrombotic events such as deep venous thrombosis (DVT), pulmonary embolism (PE) and disseminated intravascular coagulation (DIC).

The D-Dimer assay is used to help rule out DVT or PE and to monitor therapy in DIC. The reaction is obtained through latex particles coated with a monoclonal antibody directed against D-dimer. In the presence of D-dimer the latex particles will aggregate and an optical or a viscosity change can be measured depending on the instrument technology.

Latex immunoassay

Adoptable to most 350-900 nm measuring systems

Excellent correlation between 405 nm / 660 nm/ 800 nm methods

High sensitivity, low cut-off value (200 ng/mL) for a high exclusion rate of DVT and PE

Sensitivity & specificity

Details & typical data

Product form: Liquid components
Available volumes: • MRX147: 3 mL latex + 7 mL reaction buffer
• MRX147B: 6 mL latex diluted + 7 mL reaction buffer
• MRX143: 4 mL latex + 7 mL reaction buffer
• Other filling volumes upon request
Origin: Monoclonal antibodies
Additional products needed: • Eximius Control Basic or Plus (L1/L2/L3) (MRX170-MRX173, MRX180-MRX183)
• Scandinavian Controls Multi and Multi Plus (GHI162/GHI167B, GHI164/GHI170)
• D-Dimer Calibrator (MRX144)
• Sample Diluent (0,9 % NaCl) for calibrator dilutions (MRX184)

Parameters: MRX147, MRX147B MRX143
Wavelength: 400-600 nm 600-800 nm
Sensitivity: 99% NPV using 200 ng/mL cut off 98% NPV using 200 ng/mL cut off
Hook effect: No Hook effect <100 000 ng/mL No Hook effect <130 000 ng/mL
Dynamic range: 41,3 - 1000 000 pg/mL 41,3 - 1000 000 pg/mL
Specificity: >100-fold specificity for D-dimer (Fibrin or purified D-dimer), over Fibrinogen, Fibrinogen D or Fragment E >100-fold specificity for D-dimer (Fibrin or purified D-dimer), over Fibrinogen, Fibrinogen D or Fragment E
Interfering substances: No interferences with UF and LMW Heparin <100 U/mL Bilirubin < 0,1 g/L Triglycerides <2,5 g/L Hemoglobin <4 g/L No interferences with UF and LMW Heparin <100 U/mL Bilirubin <0,5 g/L Triglycrides <20 g/L Hemoglobin <10 g/L

Stability & storage

Storage: 2-8 °C
Shelf-life: 18 months at 2-8 °C
Open vial stability: 4 weeks at 2-25 °C

Ordering information

Ref. No Product description Size
MRX147 MRX D-Dimer (latex + reaction buffer) 5x3 mL + 5x7 mL
MRX147B MRX D-Dimer (latex diluted + reaction buffer) 5x6 mL + 5x7 mL
MRX143 MRX D-Dimer (latex + reaction buffer) 5x4 mL + 5x7 mL
MRX170 Eximius Control Basic, L1+L2+L3 4+4+2x1 mL
MRX171/172/173 Eximius Control Basic, L1/L2/L3 10x1 mL pack per level
MRX180 Eximius Control Plus, L1+L2+L3 4+4+2x1 mL
MRX181/182/183 Eximius Control Plus, L1/L2/L3 10x1 mL pack per level
GHI162/167B Scandinavian Control Multi, L1/L2 10x1 mL pack per level
GHI164/170 Scandinavian Control Multi Plus, L1/L2 10x1 mL pack per level
MRX144 D-Dimer Calibrator 1x1 mL
MRX184 Sample Diluent (0,9 % NaCl) 10x8 mL
 
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