MRX PT Quick

PT reagent from rabbit brain origin with an ISI ~1 for responsive determination of Prothrombin Time in citrated human plasma.

PT Quick is the internationally most common method to measure Prothrombin Time (PT), and is normally the assay of choice to monitor oral anticoagulat therapy. Moreover, PT Quick is used as a fundamental screening test for acquired or inherited bleeding disorders. 

Low ISI ~1

Calibrated against WHO international reference preparation RBT/05

Excellent stability

Applicable on optical and mechanical instruments

 

General description

The PT is the method of choice for monitoring oral anticoagulant therapy and is a fundamental screening test for acquired or inherited bleeding disorders. During oral anti-coagulant therapy, the activity of vitamin K-dependant clotting factors (FII, FVII, FIX, FX, protein C and protein S) is reduced and PT time is increased thereby enable the quantitative determination of prothrombin activity.

MRX PT Quick is a highly sensitive diagnostic reagent intended for use in performing PT tests. MRX PT Quick reagent contains a source of rabbit tissue thromboplastin and calcium that specifically activate FVII in the extrinsic coagulation pathway. MRX PT Quick reagent is easy to reconstitute, calcium is already added to the reagent before lyophilisation. Calibration was performed against the most recent WHO thromboplastin standard, RBT/05, which is traceable to the first reference preparation of thromboplastins. The calibration assures low lot-to-lot variation and consequently results in reliable PT determination.

PT Quick results are expressed in either seconds, percent activity or international normalised ratio, INR. The international recommendations of reporting the PT time is INR and refers to the international sensitivity index (ISI) of thromboplastins. INR is calculated from the quotient between the coagulation time for sample and the coagulation time for a normal plasma (MNPT) raised to the method’s ISI-value (International Sensitivity Index).

INR = (PT/MNPT)ISI

PT Quick vs PT Owren’s

Sensitivity & specificity

Details & typical data

Product form: Lyophilised
Available volumes: • 2 mL
• 4 mL
• 5 mL
• 10 mL
Origin: Rabbit brain thromboplastin
Additional product requirements: • Diluent (GHI154) or CLSI CLRW type water or equivalent
• Eximius Control Basic or Plus (L1/L2/L3) (MRX170-173, MRX180-183)
• Multi Calibrator II (MRX1203) or PT 6-Level Calibrator (MRX1205)
Expected ISI value: 0,9 - 1,2
Factor sensitivity: FI, FII, FV, FVII and FX
No interferences with: Heparin UFH <2 U/mL, Triglycerides <5 g/L, Bilirubin <500 mg/L, Hemoglobin <5 g/L

Stability & storage

Storage: 2-8 °C
Shelf-life: 24 months at 2-8 °C
Reconstituted solution: 5 days at 2-25 °C

Ordering information

Reference number Product description Pack size
MRX943-2 MRX PT Quick 10x2 mL
MRX943-4 MRX PT Quick 10x4 mL
MRX943-5 MRX PT Quick 10x5 mL
MRX943-10 MRX PT Quick 10x10 mL
MRX170 Eximius Control Basic L1+L2+L3 4+4+2x1 mL
MRX171/172/173 Eximius Control Basic L1/L2/L3 10x1 mL pack per level
MRX180 Eximius Control Plus L1+L2+L3 4+4+2x1 mL
MRX181/182/183 Eximius Control Plus L1/L2/L3 10x1 mL pack per level
MRX1203 Multi Calibrator II (AT, fibrinogen, PT Quick) 1x1 mL
MRX1203-10 Multi Calibrator II (AT, fibrinogen, PT Quick) 10x1 mL
MRX1205 PT 6-Level Calibrator (INR 1-6) 6x1 mL
GHI154-2 Diluent (CLSI CLRW type water) 10x2 mL
GHI154-4 Diluent (CLSI CLRW type water) 10x4 mL
GHI154-5 Diluent (CLSI CLRW type water) 10x5 mL
GHI154-10 Diluent (CLSI CLRW type water) 10x10 mL

MRX PT Quick product line

Item & description
Pack size

MRX943-2

PT Quick, 2 mL

10x2 mL

MRX943-5

PT Quick, 5 mL

10x5 mL

MRX943-10

PT Quick, 10 mL

10x10 mL

MRX943-4

PT Quick, 4 mL

10x4 mL

MRX171

Eximius Control Basic L1

10x1 mL

MRX172

Eximius Control Basic L2

10x1 mL

MRX173

Eximius Control Basic L3

10x1 mL

MRX181

Eximius Control PLUS L1

10x1 mL

MRX182

Eximius Control PLUS L2

10x1 mL

MRX183

Eximius Control PLUS L3

10x1 mL

 
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