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MRX Fib Clauss

Lyophilised reagents for quantifying fibrinogen in human citrated plasma, according to the Clauss method.

Fibrinogen Clauss (Fib Clauss) is the internationally most established method to determine fibrinogen in human plasma, which is of clinical importance when unexplained bleeding occurs. To fullfill the market requirements and needs MediRox has developed two different designs of Fib Clauss reagents, one having 100 UNIH/mL thrombin being highly resistent to dabigatran and one having 29 UNIH/mL thrombin suitable for the more price sensitive markets where negigible amount dabigatran is prescribed.

 

 

Two Fib Clauss products (100 UNIH/mL and 29 UNIH/mL bovine thrombin)

Linearity up to 8 g/L

High stability

 

General Description

MRX Fib Clauss is a functional assay used for the quantitative measurement of fibrinogen in human citrated plasma according to the Clauss technique, where a high concentration of thrombin is added to diluted plasma and the clotting time is measured. The result is compared with a calibration curve using a reference plasma with known fibrinogen concentrations, and a result in g/L or mg/dL is obtained. 

 

Sensitivity & Specificity

Details & typical data

Product form: Lyophilised
Fib Clauss products: • MRX942 (29 UNIH/mL thrombin)
• MRX942B (100 UNIH/mL thrombin)
Available volumes: • 2 mL for both MRX942 and MRX942B
• 5 mL for both MRX942 and MRX942B
Origin: Bovine thrombin
Additional products needed: • Diluent (GHI154) or CLSI CLRW type water or equivalent
• Sample Diluent (0,9% NaCl) for sample and calibrator dilutions (MRX184)
• Eximius Control Basic or Plus (L1/L2/L3) (MRX170-MRX173, MRX180-MRX183)
• Scandinavian Controls Basic, Multi and Multi Plus (L1/L2) (GHI163/GHI169; GHI164/GHI170; GHI164 GHI170)
• Fib Clauss Calibrator (MRX1204), Multi Calibrator I (MRX1202) or Multi Calibrator II (MRX1203)
• Imidazol Buffer (MRX185-15) required for some instruments

Details: MRX942 MRX942B
Linearty: Linear calibration from 0,6-6,0 g/L Linear calibration from 0,6-8,0 g/L
Expected values: 1,59-3,51 g/L 1,59-3,51 g/L
Interfering substances: No interferences with Bilirubin <50 mg/L, Heparin <1,0 IU/mL, Triglycerides <3,75 g/L, Hemoglobin <0,375 g/L, Dabigatran <100 μg/L No interferences with Bilirubin <50 mg/L, Heparin <4,0 IU/mL, Triglycerides <3,75 g/L, Dabigatran <475 μg/L, Haemolyzed plasma should not be assayed

Stability & storage

Storage: 2-8 °C
Shelf-life: 24 months at 2-8 °C
Reconstituted solution: 7 days at 2-25 °C

Ordering information

Reference number Product description Pack size
MRX942B-2 MRX Fib Clauss, 100 UNIH/mL 10x2 mL
MRX942B MRX Fib Clauss, 100 UNIH/mL 10x5 mL
MRX942-2 MRX Fib Clauss, 29 UNIH/mL 10x2 mL
MRX942 MRX Fib Clauss, 29 UNIH/mL 10x5 mL
MRX170 Eximius Control Basic, L1+L2+L3 4+4+2x1 mL
MRX171/172/173 Eximius Control Basic, L1/L2/L3 10x1 mL pack per level
MRX180 Eximius Control Plus, L1+L2+L3 4+4+2x1 mL
MRX181/182/183 Eximius Control Plus, L1/L2/L3 10x1 mL pack per level
GHI163/169 Scandinavian Control Basic, L1/L2 10x1 mL pack per level
GHI162/167B Scandinavian Control Multi, L1/L2 10x1 mL pack per level
GHI164/170 Scandinavian Control Multi Plus, L1/L2 10x1 mL pack per level
MRX1204 Fib Clauss Calibrator 1x1 mL
MRX1202 Multi Calibrator I (AT, fibrinogen, D-dimer) 1x1 mL
MRX1203 Multi Calibrator II (PT Quick, AT, fibrinogen) 1x1 mL
GHI154 Diluent (CLSI CLRW type water) 10x5 mL
MRX184 Sample Diluent (0,9 % NaCl) 10x8 mL
MRX185-15 Imidazol Buffer 10x15 mL

MRX Fib Clauss product line

Item & description
Pack size

MRX942-2

MRX Fib Clauss (29), 2 mL

10x2 mL

MRX942-5

MRX Fib Clauss (29), 5 mL

10x5 mL

MRX942B-5

MRX Fib Clauss (100), 5 mL

10x5 mL

MRX171

Eximius Control Basic L1

10x1 mL

MRX172

Eximius Control Basic L2

10x1 mL

MRX173

Eximius Control Basic L3

10x1 mL

MRX181

Eximius Control PLUS L1

10x1 mL

MRX182

Eximius Control PLUS L2

10x1 mL

MRX183

Eximius Control PLUS L3

10x1 mL

MRX1202

Multi Calibrator I (AT, Fib, DD) intended for calibration of AT, Fib Clauss and D-Dimer assays.

1x1 mL (MRX1202)

10x1 mL (MRX1202-10)

MRX1203

Multi Calibrator II (AT, Fib, PT) intended for calibration of AT, Fib Clauss and PT assays. PT is obtained as PT %. 

1x1 mL (MRX1203)

10x1 mL (MRX1203-10)

 
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