Fibrinogen Clauss (Fib Clauss) is the internationally most established method to determine fibrinogen in human plasma, which is of clinical importance when unexplained bleeding occurs. To fullfill the market requirements and needs MediRox has developed two different designs of Fib Clauss reagents, one having 100 UNIH/mL thrombin being highly resistent to dabigatran and one having 29 UNIH/mL thrombin suitable for the more price sensitive markets where negigible amount dabigatran is prescribed.
Two Fib Clauss products (100 UNIH/mL and 29 UNIH/mL bovine thrombin)
Lyophilised reagents, reconstituted in distilled water
Large measuring range
MRX Fib Clauss is a functional assay used for the quantitative measurement of fibrinogen in human citrated plasma according to the Clauss technique, where a high concentration of thrombin is added to diluted plasma and the clotting time is measured. The result is compared with a calibration curve using a reference plasma with known fibrinogen concentrations, and a result in g/L or mg/dL is obtained.
Sensitivity & Specificity
Details & Typical Data, MRX942B
|Thrombin content:||100 UNIH/mL|
|Sensitivity:||Linear calibration from 0,6 -8,0 g/L|
|Specificity:||CV <6,3 % for the normal control within and between runs|
|Interfering substances:||No interferences with Bilirubin <50 mg/L, Heparin <4,0 IU/mL, Triglycerides <3,8 g/L, Dabigatran <475 μg/L|
Details & Typical Data, MRX942
|Thrombin content:||29 UNIH/mL|
|Sensitivity:||Linear calibration from 0,6 -6,0 g/L|
|Specificity:||CV <4,7 % for the normal control within and between runs|
|Interfering substances:||No interferences with Bilirubin <50 mg/L, Heparin <1,0 IU/mL, Triglycerides <2,5 g/L, Hemoglobin <0,38 g/L|
Stability & Storage
|Shelf life:||24 months at 2-8 °C|
|Reconstituted solution:||7 days at 2-25 °C|
|Reference Number||Product Description||Pack Size|
|MRX942B-5||MRX Fib Clauss, 100 UNIH/mL||10x5 mL|
|MRX942B-2||MRX Fib Clauss, 100 UNIH/mL||10x2 mL|
|MRX942-5||MRX Fib Clauss, 29 UNIH/mL||10x5 mL|
|MRX942-2||MRX Fib Clauss, 29 UNIH/mL||10x2 mL|
|MRX1202||Multi Calibrator I (Fib, AT, DD)||1x1 mL|
|MRX1202-10||Multi Calibrator I (Fib, AT, DD)||10x1 mL|
|MRX1203||Multi Calibrator II (Fib, AT, PT)||1x1 mL|
|MRX1203-10||Multi Calibrator II (Fib, AT, PT)||10x1 mL|
|MRX1204||Fib Clauss Calibrator||1x1 mL|
|MRX171/172/173||Eximius Control Basic, L1/L2/L3||10x1 mL pack per level|
|MRX181/182/183||Eximius Control PLUS, L1/L2/L3||10x1 mL pack per level|
|MRX184-8||Sample Diluent (0,9% NaCl)||10x8 mL|
|GHI154-5||Diluent (pur. water, reconst.)||10x5 mL|
|GHI154-2||Diluent (pur. water, reconst.)||10x2 mL|
MRX Fib Clauss product line
MRX942-2MRX Fib Clauss (29), 2 mL
MRX942-5MRX Fib Clauss (29), 5 mL
MRX942B-5MRX Fib Clauss (100), 5 mL
MRX171Eximius Control Basic L1
MRX172Eximius Control Basic L2
MRX173Eximius Control Basic L3
MRX181Eximius Control PLUS L1
MRX182Eximius Control PLUS L2
MRX183Eximius Control PLUS L3
Multi Calibrator I (AT, Fib, DD) with specified levels of fibrinogen, antithrombin and D-dimer can be successfully used when calibration of multiple assays is requested.
1x1 mL (MRX1202)
10x1 mL (MRX1202-10)
Multi Calibrator II (AT, Fib, PT) with specified levels of fibrinogen, antithrombin and PT can be successfully used when calibration of multiple assays is requested.
1x1 mL (MRX1203)
10x1 mL (MRX1203-10)
All Coagulation Reagents
Liquid compontent kits containing phospholipid extract and silica contact activator. Sensitive to heparin as well as factors and insensitive to lupus anticoagulant.
FXa-based chromogenic assay consisting of liquid components for quantifying functional Antithrombin activity in human citrated plasma.
MRX PT Quick
PT reagent from rabbit brain origin with an ISI ~1 for responsive determination of Prothrombin Time in citrated human plasma.
Latex-based liquid component kits for quantifying D-dimer fragments in human citrated plasma using readers with wavelengths 350-900nm.
MRX Owren’s PT
The predominantly used PT method in Scandinavia due to the high sensitivity to interferences. The assay can be used with both whole blood and plasma.
MRX Thrombin Time
Two different lyophilised reagents for detection of fibrinogen abnormalities, and the presence of heparin and other thrombin inhibitors in human citrated plasma.