Medirox D-Dimer series is developed for unified D-dimer reporting across multiple systems. Each reagent in the series utilizes the same monoclonal antibody, but is suitable for different systems, ensuring a coverage of most measuring systems. The reagent series is composed of three different assays, MRX143 made to work on measuring systems using red light, and two different reagents MRX147 and MRX 147B for blue light. MRX147 is designed to work on semi- and fully automated instruments with short beam paths, whereas MRX147B is designed to work on the classic instruments having a wider beam path.
Latex based assay
Liquid components, ready to use
Adoptable to most 350-900 nm measuring systems
Excellent correlation between 405 nm / 660 nm / 800 nm methods
High sensitivity, low cut-off value (200 ng/mL) for a high exclusion
rate of DVT and PE
D-dimer is a key indicator of thrombotic events such as deep venous thrombosis (DVT), pulmonary embolism (PE) and disseminated intravascular coagulation (DIC). MRX D-Dimer is used to exclude a diagnosis of DVT or PE and to monitor therapy in DIC.
The reaction is obtained through latex particles coated with a monoclonal antibody directed against D-dimer. In the presence of D-dimer the latex particles will aggregate and an optical change can be measured. An obstacle in standardising D-dimer reporting has been that manufacturers of instrument have developed reagents based on a unique series of monoclonal antibodies.
This has led to a variation in results between systems, and besides the risk of confusion regarding patient results it complicates all forms of external control programs. MediRox series of D-Dimer is unique to share one monoclonal antibody for all reagents. With the same antibody MRX143 and MRX147/147B can be used on most reading devices, and can be jointly calibrated.
Sensitivity & specificity
Details & typical data, MRX147/147B
|Product form:||Liquid components|
• MRX147 kit: 3 mL latex + 7 mL reaction buffer
• MRX147B kit: 6 mL latex diluted + 7 mL reaction buffer
• MRX143 kit: 4 mL latex + 7 mL reaction buffer
• Other filling volumes upon request
|Additional products needed:||
• Eximius Control Basic or Plus (L1/L2/L3) (MRX170-MRX173, MRX180-MRX183)
• Scandinavian Controls Multi and Multi Plus (GHI162/GHI167B, GHI164/GHI170)
• D-Dimer Calibrator (MRX144) or Multi Calibrator I (MRX1202)
• Sample Diluent (0,9 % NaCl) for calibrator dilutions (MRX184)
|Wavelength:||400-600 nm||600-800 nm|
|Sensitivity:||99% NPV using 200 ng/mL cut off||98% NPV using 200 ng/mL cut off|
|Hook effect:||No Hook effect <100 000 ng/mL||No Hook effect <130 000 ng/mL|
|Dynamic range:||41,3 - 1000 000 pg/mL||41,3 - 1000 000 pg/mL|
|Specificity:||>100-fold specificity for D-dimer (Fibrin or purified D-dimer), over Fibrinogen, Fibrinogen D or Fragment E||>100-fold specificity for D-dimer (Fibrin or purified D-dimer), over Fibrinogen, Fibrinogen D or Fragment E|
|Interfering substances:||No interferences with UF and LMW Heparin <100 U/mL Bilirubin < 0,1 g/L Triglycerides <2,5 g/L Hemoglobin <4 g/L||No interferences with UF and LMW Heparin <100 U/mL Bilirubin <0,5 g/L Triglycrides <20 g/L Hemoglobin <10 g/L|
Stability & storage
|Shelf-life:||18 months at 2-8 °C|
|Open vial stability:||4 weeks at 2-25 °C|
|Reference number||Product description||Pack size|
|MRX147||MRX D-Dimer (latex + reaction buffer)||5x3 mL + 5x7 mL|
|MRX147B||MRX D-Dimer (latex diluted + reaction buffer)||5x6 mL + 5x7 mL|
|MRX143||MRX D-Dimer (latex + reaction buffer)||5x4 mL + 5x7 mL|
|MRX170||Eximius Control Basic, L1+L2+L3||4+4+2x1 mL|
|MRX171/172/173||Eximius Control Basic, L1/L2/L3||10x1 mL pack per level|
|MRX180||Eximius Control Plus, L1+L2+L3||4+4+2x1 mL|
|MRX181/182/183||Eximius Control Plus, L1/L2/L3||10x1 mL pack per level|
|GHI162/167B||Scandinavian Control Multi, L1/L2||10x1 mL pack per level|
|GHI164/170||Scandinavian Control Multi Plus, L1/L2||10x1 mL pack per level|
|MRX144||D-Dimer Calibrator||1x1 mL|
|MRX1202||Multi Calibrator I (AT, fibrinogen, D-dimer)||1x1 mL|
|MRX184||Sample Diluent (0,9 % NaCl)||10x8 mL|
MRX D-Dimer product line
MRX143600-800 nm D-Dimer Kit
5x4 mL Latex
5x7 mL Reaction Buffer
MRX147B400-600 nm D-Dimer Kit, pre-diluted
5x6 mL Latex
5x7 mL Reaction Buffer
MRX147400-600 nm D-Dimer Kit, conc
5x3 mL Latex
5x7 mL Reaction Buffer
MRX171Eximius Control Basic L1
MRX172Eximius Control Basic L2
MRX173Eximius Control Basic L3
MRX181Eximius Control PLUS L1
MRX182Eximius Control PLUS L2
MRX183Eximius Control PLUS L3
D-Dimer Calibrator for calibration of MRX D-Dimer assays (MRX147B/MRX147/MRX143), suitable for instrument readers with wavelengths of 400-600 nm or 600-800 nm.
Multi Calibrator I (AT, Fib, DD) intended for calibration of AT, Fib Clauss and D-Dimer assays.
1x1 mL (MRX1202)
10x1 mL (MRX1202-10)
All Coagulation Reagents
Latex-based liquid components for quantifying free Protein S in human citrated plasma using readers with wavelengths 600-800nm.
MRX Fib Clauss
Lyophilised reagents for quantifying fibrinogen in human citrated plasma, according to the Clauss method.
MRX PT Owren’s
The predominantly used PT method in Scandinavia due to the high sensitivity to interferences. The assay can be used with both whole blood and plasma.
MRX Thrombin Time
Two different lyophilised reagents for detection of fibrinogen abnormalities, and the presence of heparin and other thrombin inhibitors in human citrated plasma.
Liquid compontent kits containing phospholipid extract and silica contact activator. Sensitive to heparin as well as factors and insensitive to lupus anticoagulant.
FXa-based chromogenic assay consisting of liquid components for quantifying functional Antithrombin activity in human citrated plasma.
MRX PT Quick
PT reagent from rabbit brain origin with an ISI ~1 for responsive determination of Prothrombin Time in citrated human plasma.