MRX D-Dimer

Latex-based liquid component kits for quantifying D-dimer fragments in human citrated plasma using readers with wavelengths 350-900nm.

MediRox D-Dimer series is a further developed D-Dimer Kit utilising the same monoclonal antibody in three different reagents, making it suitable to most measuring systems. Thereby a unified D-dimer reporting can be achieved between different brands of equipment and measuring methods.

Latex based assay

Liquid components, ready to use

Adoptable to most 350-900 nm measuring systems

Excellent correlation between 405 nm / 660 nm/ 800 nm methods

 

General Description

D-dimer is a key indicator of thrombotic events such as deep venous thrombosis (DVT), pulmonary embolism (PE) and disseminated intravascular coagulation (DIC). MRX D-Dimer is used to exclude a diagnosis of DVT or PE and to monitor therapy in DIC.

 

Performance Characteristics

The reaction is obtained through latex particles coated with a monoclonal antibody directed against D-dimer. In the presence of D-dimer the latex particles will aggregate and an optical change can be measured. An obstacle in standardising D-dimer reporting has been that manufacturers of instrument have developed reagents based on a unique series of monoclonal antibodies. 

This has led to a variation in results between systems, and besides the risk of confusion regarding patient results it complicates all forms of external control programs. MediRox series of D-Dimer is unique to share one monoclonal antibody for all reagents. With the same antibody MRX143 and MRX147/147B can be used on most reading devices, and can be jointly calibrated.

Sensitivity & Specificity

Details & Typical Data, MRX147/147B

Product form: Liquid components
Wavelength: 400-600 nm
Sensitivity: 99% NPV using 200 ng/mL cut off
Hook Effect: No Hook effect <100 000 ng/mL
Dynamic Range: 41,3 - 1000 000 pg/mL
Specificity: >100-fold specificity for D-dimer (Fibrin or purified D-dimer), over Fibrinogen, Fibrinogen D or Fragment E
Interfering substances: No interferences with UF and LMW Heparin <100 U/mL, Bilirubin < 0,1 g/L, Triglycerides <2,5 g/L, Hemoglobin <4 g/L

Details & Typical Data, MRX143

Product form: Liquid components
Wavelength: 600-800 nm
Sensitivity: 98% NPV using 200 ng/mL cut off
Hook Effect: No Hook effect <130 000 ng/mL
Dynamic Range: 41,3 - 1000 000 pg/mL
Specificity: >100-fold specificity for D-dimer (Fibrin or purified D-dimer), over Fibrinogen, Fibrinogen D or Fragment E
Interfering substances: No interferences with UF and LMW Heparin <100 U/mL, Bilirubin <0,5 g/L, Lipids <20 g/L, Hemoglobin <10 g/L

Stability & Storage

Parameters MRX147/MRX147B and MRX143
Storage: 2-8 °C
Shelf life: 18 months from manufacturing date at 2-8 °C
Open vial stability: 4 weeks at 2-8 °C

Ordering Information

Reference Number Product Description Pack Size
MRX147 400-600 nm D-Dimer Kit, conc 5x3 mL Latex 5x7 mL Reaction buffer
MRX147B 400-600 nm D-Dimer Kit, pre-diluted 5x6 mL Latex 5x7 mL Reaction Buffer
MRX143 600-800 nm D-Dimer Kit 5x4 mL Latex 5x7 mL Reaction Buffer
MRX144 D-Dimer Calibrator (DDU and FEU) 1x1 mL
MRX1202 Multi Calibrator I (AT, Fib, DD) 1x1 mL 10x1 mL
MRX171/172/173 Eximius Control Basic, L1/L2/L3 10x1 mL pack per level
MRX181/182/183 Eximius Control PLUS, L1/L2/L3 10x1 mL pack per level

MRX D-Dimer product line

Item & description
Pack size

MRX143

600-800 nm D-Dimer Kit

5x4 mL Latex
5x7 mL Reaction Buffer

MRX147B

400-600 nm D-Dimer Kit, pre-diluted

5x6 mL Latex
5x7 mL Reaction Buffer

MRX147

400-600 nm D-Dimer Kit, conc

5x3 mL Latex
5x7 mL Reaction Buffer

MRX171

Eximius Control Basic L1

10x1 mL

MRX172

Eximius Control Basic L2

10x1 mL

MRX173

Eximius Control Basic L3

10x1 mL

MRX181

Eximius Control PLUS L1

10x1 mL

MRX182

Eximius Control PLUS L2

10x1 mL

MRX183

Eximius Control PLUS L3

10x1 mL

MRX144

D-Dimer Calibrator for D-Dimer assays, suitable for instrument readers with wavelengths of 400-600 nm or 600-800 nm. 

1x1 mL

 
Order products Close

To order a desired product, send an email to order@medirox.se 

or

If you have any further thoughts or questions, don’t hesitate to call us at +46 (0)155 45 44 10.